Wikipedista:Karel Drbal/Pískoviště

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↑ [{"title":"PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis","pages":"19617-19629","ISSN":["1083-351X"],"journalAbbreviation":"J. Biol. Chem.","publicationTitle":"The Journal of Biological Chemistry","volume":"286","issue":"22","date":"Jun 3, 2011","abstractNote":"Transmembrane adaptor proteins (TRAPs) are important organizers and regulators of immunoreceptor-mediated signaling. A bioinformatic search revealed several potential novel TRAPs, including a highly conserved protein, proline rich 7 (PRR7), previously described as a component of the PSD-95/N-methyl-d-aspartate receptor protein complex in postsynaptic densities (PSD) of rat neurons. Our data demonstrate that PRR7 is weakly expressed in other tissues but is readily up-regulated in activated human peripheral blood lymphocytes. Transient overexpression of PRR7 in Jurkat T cell line led to gradual apoptotic death dependent on the WW domain binding motif surrounding Tyr-166 in the intracellular part of PRR7. To circumvent the pro-apoptotic effect of PRR7, we generated Jurkat clones with inducible expression of PRR7 (J-iPRR7). In these cells acute induction of PRR7 expression had a dual effect. It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment. On the other hand, expression of PRR7 inhibited general tyrosine phosphorylation and calcium influx after T cell receptor cross-linking by antibodies. Moreover, we found PRR7 constitutively tyrosine-phosphorylated and associated with Src. Collectively, these data indicate that PRR7 is a potential regulator of signaling and apoptosis in activated T cells.","DOI":"10.1074/jbc.M110.175117","extra":"PMID: 21460222\nPMCID: PMC3103341","libraryCatalog":"PubMed","url":"http://www.ncbi.nlm.nih.gov/pubmed/21460222","accessDate":"2015-06-02","author":[["Matous","Hrdinka"],["Peter","Dráber"],["Ondrej","Stepánek"],["Tereza","Ormsby"],["Pavel","Otáhal"],["Pavla","Angelisová"],["Tomás","Brdicka"],["Jan","Paces"],["Václav","Horejsí"],["Karel","Drbal"]],"PMID":"21460222","PMCID":"3103341"}]
↑ PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. www.ncbi.nlm.nih.gov. S. 19617-19629. Dostupné online. ISSN 1083-351X. DOI 10.1074/jbc.M110.175117. PMID 21460222.
↑ OTÁHAL, Pavel; ANGELISOVÁ, Pavla; HRDINKA, Matouš; BRDIČKA, Tomáš; NOVÁK, Petr; DRBAL, Karel; HOŘEJŠÍ, Václav. A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling. The Journal of Immunology. 04/01/2010, s. 3689-3696. Dostupné online. ISSN 0022-1767. DOI 10.4049/jimmunol.0902075. PMID 20207997. (anglicky)
↑ HRDINKA, M.; DRÁBER, P.; STEPÁNEK, O., et al. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. J Biol Chem.. 2011, roč. 286, čís. 22, s. 19617-29. Dostupné online. ISSN 1083-351X.
↑ WU, Hong; WANG, Jun; WANG, Zhemin; FISHER, Darrell R.; LIN, Yuehe. Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapy of cancers. Journal of Nanoscience and Nanotechnology. 2008-05, s. 2316–2322. ISSN 1533-4880. PMID 18572643.
↑ OTÁHAL, Pavel; ANGELISOVÁ, Pavla; HRDINKA, Matouš; BRDIČKA, Tomáš; NOVÁK, Petr; DRBAL, Karel; HOŘEJŠÍ, Václav. A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling. The Journal of Immunology. 04/01/2010, s. 3689-3696. Dostupné online. ISSN 0022-1767. DOI 10.4049/jimmunol.0902075. PMID 20207997. (anglicky)
↑ WU, Hong; WANG, Jun; WANG, Zhemin; FISHER, Darrell R.; LIN, Yuehe. Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapy of cancers. Journal of Nanoscience and Nanotechnology. 2008-05, s. 2316–2322. ISSN 1533-4880. PMID 18572643.

[1] [{"title":"PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis","pages":"19617-19629","ISSN":["1083-351X"],"journalAbbreviation":"J. Biol. Chem.","publicationTitle":"The Journal of Biological Chemistry","volume":"286","issue":"22","date":"Jun 3, 2011","abstractNote":"Transmembrane adaptor proteins (TRAPs) are important organizers and regulators of immunoreceptor-mediated signaling. A bioinformatic search revealed several potential novel TRAPs, including a highly conserved protein, proline rich 7 (PRR7), previously described as a component of the PSD-95/N-methyl-d-aspartate receptor protein complex in postsynaptic densities (PSD) of rat neurons. Our data demonstrate that PRR7 is weakly expressed in other tissues but is readily up-regulated in activated human peripheral blood lymphocytes. Transient overexpression of PRR7 in Jurkat T cell line led to gradual apoptotic death dependent on the WW domain binding motif surrounding Tyr-166 in the intracellular part of PRR7. To circumvent the pro-apoptotic effect of PRR7, we generated Jurkat clones with inducible expression of PRR7 (J-iPRR7). In these cells acute induction of PRR7 expression had a dual effect. It resulted in up-regulation of the transcription factor c-Jun and the activation marker CD69 as well as enhanced production of IL-2 after phorbol 12-myristate 13-acetate (PMA) and ionomycin treatment. On the other hand, expression of PRR7 inhibited general tyrosine phosphorylation and calcium influx after T cell receptor cross-linking by antibodies. Moreover, we found PRR7 constitutively tyrosine-phosphorylated and associated with Src. Collectively, these data indicate that PRR7 is a potential regulator of signaling and apoptosis in activated T cells.","DOI":"10.1074/jbc.M110.175117","extra":"PMID: 21460222\nPMCID: PMC3103341","libraryCatalog":"PubMed","url":"http://www.ncbi.nlm.nih.gov/pubmed/21460222","accessDate":"2015-06-02","author":[["Matous","Hrdinka"],["Peter","Dráber"],["Ondrej","Stepánek"],["Tereza","Ormsby"],["Pavel","Otáhal"],["Pavla","Angelisová"],["Tomás","Brdicka"],["Jan","Paces"],["Václav","Horejsí"],["Karel","Drbal"]],"PMID":"21460222","PMCID":"3103341"}]

[2] PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. www.ncbi.nlm.nih.gov. S. 19617-19629. Dostupné online. ISSN 1083-351X. DOI 10.1074/jbc.M110.175117. PMID 21460222.

[3] OTÁHAL, Pavel; ANGELISOVÁ, Pavla; HRDINKA, Matouš; BRDIČKA, Tomáš; NOVÁK, Petr; DRBAL, Karel; HOŘEJŠÍ, Václav. A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling. The Journal of Immunology. 04/01/2010, s. 3689-3696. Dostupné online. ISSN 0022-1767. DOI 10.4049/jimmunol.0902075. PMID 20207997. (anglicky)

[4] HRDINKA, M.; DRÁBER, P.; STEPÁNEK, O., et al. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. J Biol Chem.. 2011, roč. 286, čís. 22, s. 19617-29. Dostupné online. ISSN 1083-351X.

[5] WU, Hong; WANG, Jun; WANG, Zhemin; FISHER, Darrell R.; LIN, Yuehe. Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapy of cancers. Journal of Nanoscience and Nanotechnology. 2008-05, s. 2316–2322. ISSN 1533-4880. PMID 18572643.

[6] OTÁHAL, Pavel; ANGELISOVÁ, Pavla; HRDINKA, Matouš; BRDIČKA, Tomáš; NOVÁK, Petr; DRBAL, Karel; HOŘEJŠÍ, Václav. A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling. The Journal of Immunology. 04/01/2010, s. 3689-3696. Dostupné online. ISSN 0022-1767. DOI 10.4049/jimmunol.0902075. PMID 20207997. (anglicky)

[7] WU, Hong; WANG, Jun; WANG, Zhemin; FISHER, Darrell R.; LIN, Yuehe. Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapy of cancers. Journal of Nanoscience and Nanotechnology. 2008-05, s. 2316–2322. ISSN 1533-4880. PMID 18572643.

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